Drug interactions
Diazepam intranasal + Mifepristone
Severity: Moderate
Diazepam intranasal and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may slow diazepam elimination. This can prolong sedation and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by mifepristone reduces diazepam clearance.
What to do
Monitor for excess sedation and respiratory depression, particularly after repeated doses. Counsel the patient and caregivers about increased drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Mifepristone?
MediHelp rates the interaction as moderate. Diazepam intranasal and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may slow diazepam elimination. This can prolong sedation and respiratory depression.
How serious is the interaction between Diazepam intranasal and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression, particularly after repeated doses. Counsel the patient and caregivers about increased drowsiness.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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