Drug interactions
Diazepam intranasal + Milnacipran
Severity: Moderate
Diazepam intranasal and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam causes CNS and respiratory depression, and milnacipran can cause dizziness and somnolence. Combined use may increase sedation and impair psychomotor performance, though milnacipran has limited sedative effect.
What this interaction means in plain words
Diazepam intranasal and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, with benzodiazepine GABA-A enhancement.
What to do
Counsel patients on drowsiness and avoiding driving or alcohol. Use the lowest effective diazepam dose and monitor sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Milnacipran?
MediHelp rates the interaction as moderate. Diazepam intranasal and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam causes CNS and respiratory depression, and milnacipran can cause dizziness and somnolence. Combined use may increase sedation and impair psychomotor performance, though milnacipran has limited sedative effect.
How serious is the interaction between Diazepam intranasal and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on drowsiness and avoiding driving or alcohol. Use the lowest effective diazepam dose and monitor sedation.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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