Drug interactions
Diazepam intranasal + Nicardipine
Severity: Minor
Diazepam intranasal and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit CYP2C19 and slow diazepam elimination, potentially increasing sedation and respiratory depression. The effect is likely modest, and the pharmacodynamic additive hypotension is also possible.
What this interaction means in plain words
Diazepam intranasal and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nicardipine may weakly inhibit CYP2C19- and CYP3A4-mediated metabolism of diazepam.
What to do
Monitor for excess sedation and hypotension, especially at diazepam initiation or after repeated doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Diazepam intranasal with Nicardipine?
MediHelp rates the interaction as minor. Diazepam intranasal and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may inhibit CYP2C19 and slow diazepam elimination, potentially increasing sedation and respiratory depression. The effect is likely modest, and the pharmacodynamic additive hypotension is also possible.
How serious is the interaction between Diazepam intranasal and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and hypotension, especially at diazepam initiation or after repeated doses.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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