Drug interactions
Diazepam intranasal + Sertraline
Severity: Moderate
Diazepam intranasal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline may modestly reduce the metabolism of diazepam, leading to higher diazepam concentrations and stronger sedation or psychomotor impairment. Sertraline is a relatively weak inhibitor of the relevant enzymes, so the effect is usually modest. Both agents also affect the CNS, which can add to drowsiness.
What this interaction means in plain words
Diazepam intranasal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak inhibition of CYP2C19 and CYP3A4 by sertraline slows diazepam clearance, with additive CNS effects.
What to do
Monitor for excessive sedation, dizziness and impaired coordination, and reduce the diazepam dose if these occur. Advise patients to avoid alcohol and activities requiring alertness after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Sertraline?
MediHelp rates the interaction as moderate. Diazepam intranasal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline may modestly reduce the metabolism of diazepam, leading to higher diazepam concentrations and stronger sedation or psychomotor impairment. Sertraline is a relatively weak inhibitor of the relevant enzymes, so the effect is usually modest. Both agents also affect the CNS, which can add to drowsiness.
How serious is the interaction between Diazepam intranasal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and impaired coordination, and reduce the diazepam dose if these occur. Advise patients to avoid alcohol and activities requiring alertness after dosing.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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