Drug interactions
Diazepam intranasal + Verapamil
Severity: Moderate
Diazepam intranasal and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may slow diazepam elimination and raise diazepam exposure. This can intensify sedation, impair psychomotor performance and respiratory depression risk.
What this interaction means in plain words
Diazepam intranasal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits CYP3A4, which contributes to diazepam metabolism.
What to do
Monitor for excess sedation and respiratory depression and counsel patients about driving. Reduce the diazepam dose or frequency if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Diazepam intranasal with Verapamil?
MediHelp rates the interaction as moderate. Diazepam intranasal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may slow diazepam elimination and raise diazepam exposure. This can intensify sedation, impair psychomotor performance and respiratory depression risk.
How serious is the interaction between Diazepam intranasal and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression and counsel patients about driving. Reduce the diazepam dose or frequency if sedation is excessive.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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