Drug interactions
Diazoxide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Diazoxide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and diazoxide can raise blood glucose, and oral diazoxide is structurally related to thiazides. Combined use can cause hyperglycemia, and additive hypotension and hyperuricemia may also occur.
What this interaction means in plain words
Diazoxide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive suppression of insulin secretion and hyperglycemic effects, with additive vasodilatory and hypotensive effects.
What to do
Monitor blood glucose closely when starting the combination and adjust diazoxide or antidiabetic therapy as needed. Monitor blood pressure and uric acid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Diazoxide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and diazoxide can raise blood glucose, and oral diazoxide is structurally related to thiazides. Combined use can cause hyperglycemia, and additive hypotension and hyperuricemia may also occur.
How serious is the interaction between Diazoxide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting the combination and adjust diazoxide or antidiabetic therapy as needed. Monitor blood pressure and uric acid.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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