Drug interactions
Diazoxide + Indapamide
Severity: Moderate
Diazoxide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide-like diuretics and diazoxide can raise blood glucose, and diazoxide is also a vasodilator that can enhance hypotension. Combined use may worsen hyperglycemia, particularly in diabetic patients, and lower blood pressure further.
What this interaction means in plain words
Diazoxide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Indapamide belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effects through reduced insulin secretion, plus additive hypotensive effects.
What to do
Monitor blood glucose and blood pressure, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Indapamide?
MediHelp rates the interaction as moderate. Diazoxide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide-like diuretics and diazoxide can raise blood glucose, and diazoxide is also a vasodilator that can enhance hypotension. Combined use may worsen hyperglycemia, particularly in diabetic patients, and lower blood pressure further.
How serious is the interaction between Diazoxide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and blood pressure, and adjust antidiabetic therapy if needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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