Drug interactions
Diazoxide + Metformin
Severity: Moderate
Diazoxide and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide suppresses insulin secretion and causes hyperglycemia, directly opposing the effect of metformin. Glycemic control may deteriorate substantially.
What this interaction means in plain words
Diazoxide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Metformin belongs to Endocrine.
Why it happens
Diazoxide opens pancreatic beta-cell KATP channels, inhibiting insulin release and counteracting metformin.
What to do
Monitor blood glucose closely and increase antidiabetic therapy as needed. Reassess doses if diazoxide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Metformin?
MediHelp rates the interaction as moderate. Diazoxide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazoxide suppresses insulin secretion and causes hyperglycemia, directly opposing the effect of metformin. Glycemic control may deteriorate substantially.
How serious is the interaction between Diazoxide and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and increase antidiabetic therapy as needed. Reassess doses if diazoxide is stopped.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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