Drug interactions
Dichlorphenamide + Enalapril-hydrochlorothiazide
Severity: Moderate
Dichlorphenamide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes urinary potassium and bicarbonate loss, and combined with hydrochlorothiazide may cause marked hypokalemia and metabolic acidosis. This can provoke arrhythmias and muscle weakness.
What this interaction means in plain words
Dichlorphenamide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide diuresis.
What to do
Monitor serum potassium and bicarbonate at baseline and regularly, and give potassium supplementation if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes urinary potassium and bicarbonate loss, and combined with hydrochlorothiazide may cause marked hypokalemia and metabolic acidosis. This can provoke arrhythmias and muscle weakness.
How serious is the interaction between Dichlorphenamide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and regularly, and give potassium supplementation if needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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