Drug interactions
Dichlorphenamide + Fosinopril-hydrochlorothiazide
Severity: Moderate
Dichlorphenamide and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that increases urinary potassium loss and causes metabolic acidosis. Combined with hydrochlorothiazide, hypokalemia can be more severe, which may cause arrhythmias or weakness.
What this interaction means in plain words
Dichlorphenamide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide diuresis.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically, and correct deficits. Consider potassium supplementation if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that increases urinary potassium loss and causes metabolic acidosis. Combined with hydrochlorothiazide, hypokalemia can be more severe, which may cause arrhythmias or weakness.
How serious is the interaction between Dichlorphenamide and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically, and correct deficits. Consider potassium supplementation if levels fall.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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