Drug interactions
Dichlorphenamide + Hydrochlorothiazide-losartan
Severity: Moderate
Dichlorphenamide and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that increases urinary potassium and bicarbonate loss, so combined with hydrochlorothiazide it can produce significant hypokalemia and metabolic acidosis. Low potassium raises arrhythmia risk.
What this interaction means in plain words
Dichlorphenamide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide diuresis.
What to do
Monitor serum potassium and bicarbonate regularly, and replace potassium as needed. Adjust the dose if electrolyte abnormalities persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Dichlorphenamide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that increases urinary potassium and bicarbonate loss, so combined with hydrochlorothiazide it can produce significant hypokalemia and metabolic acidosis. Low potassium raises arrhythmia risk.
How serious is the interaction between Dichlorphenamide and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly, and replace potassium as needed. Adjust the dose if electrolyte abnormalities persist.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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