Drug interactions
Dichlorphenamide + Ipratropium-salbutamol
Severity: Moderate
Dichlorphenamide and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, promotes renal potassium loss and can cause hypokalemia and metabolic acidosis. Salbutamol also lowers serum potassium, so combined use may produce clinically significant hypokalemia with a risk of arrhythmia or muscle weakness.
What this interaction means in plain words
Dichlorphenamide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting with carbonic anhydrase inhibition and beta-2 mediated cellular potassium uptake.
What to do
Monitor serum potassium and bicarbonate regularly, particularly when salbutamol use is frequent or high-dose. Supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Dichlorphenamide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, promotes renal potassium loss and can cause hypokalemia and metabolic acidosis. Salbutamol also lowers serum potassium, so combined use may produce clinically significant hypokalemia with a risk of arrhythmia or muscle weakness.
How serious is the interaction between Dichlorphenamide and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly, particularly when salbutamol use is frequent or high-dose. Supplement potassium as needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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