Drug interactions
Dichlorphenamide + Memantine-donepezil
Severity: Moderate
Dichlorphenamide and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide can cause hypokalemia and metabolic acidosis, which increase the risk of arrhythmia. Donepezil may prolong the QT interval, so low potassium could heighten the risk of torsades de pointes. The legacy claim that donepezil lowers potassium is not well supported.
What this interaction means in plain words
Dichlorphenamide and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Carbonic anhydrase inhibition causes renal potassium loss, and hypokalemia adds to the QT-related effects of donepezil.
What to do
Monitor serum potassium and bicarbonate, and correct deficits. Obtain an ECG if the patient has cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Memantine-donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Memantine-donepezil?
MediHelp rates the interaction as moderate. Dichlorphenamide and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide can cause hypokalemia and metabolic acidosis, which increase the risk of arrhythmia. Donepezil may prolong the QT interval, so low potassium could heighten the risk of torsades de pointes. The legacy claim that donepezil lowers potassium is not well supported.
How serious is the interaction between Dichlorphenamide and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate, and correct deficits. Obtain an ECG if the patient has cardiac risk factors.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
