Drug interactions
Dichlorphenamide + Mifepristone
Severity: Moderate
Dichlorphenamide and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone at Cushing doses causes hypokalemia through glucocorticoid receptor blockade and cortisol-driven mineralocorticoid activity, and dichlorphenamide also wastes potassium. Combined use increases the risk of significant hypokalemia and arrhythmia.
What this interaction means in plain words
Dichlorphenamide and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Mifepristone belongs to Endocrine.
Why it happens
Additive potassium-lowering effects.
What to do
Monitor serum potassium regularly and supplement or give a mineralocorticoid antagonist as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Mifepristone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone at Cushing doses causes hypokalemia through glucocorticoid receptor blockade and cortisol-driven mineralocorticoid activity, and dichlorphenamide also wastes potassium. Combined use increases the risk of significant hypokalemia and arrhythmia.
How serious is the interaction between Dichlorphenamide and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and supplement or give a mineralocorticoid antagonist as needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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