Drug interactions
Dichlorphenamide + Prednisone
Severity: Moderate
Dichlorphenamide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, and together they can cause clinically significant hypokalemia. This is relevant because dichlorphenamide is used in periodic paralysis, where potassium shifts can worsen the underlying condition, and low potassium can provoke arrhythmias.
What this interaction means in plain words
Dichlorphenamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Prednisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and mineralocorticoid activity of prednisone.
What to do
Monitor serum potassium and bicarbonate regularly and replace potassium as needed. Reassess the need for the corticosteroid if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Prednisone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, and together they can cause clinically significant hypokalemia. This is relevant because dichlorphenamide is used in periodic paralysis, where potassium shifts can worsen the underlying condition, and low potassium can provoke arrhythmias.
How serious is the interaction between Dichlorphenamide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and replace potassium as needed. Reassess the need for the corticosteroid if hypokalemia persists.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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