Drug interactions
Dichlorphenamide + Propafenone
Severity: Moderate
Dichlorphenamide and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes potassium loss and metabolic acidosis. Hypokalemia increases the risk of proarrhythmia with propafenone, which is a class Ic antiarrhythmic. Propafenone itself does not typically lower serum potassium meaningfully.
What this interaction means in plain words
Dichlorphenamide and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Dichlorphenamide-induced hypokalemia and acidosis increase susceptibility to propafenone-related arrhythmias.
What to do
Monitor serum potassium and bicarbonate regularly and correct hypokalemia. Consider ECG monitoring if electrolyte disturbance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Propafenone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes potassium loss and metabolic acidosis. Hypokalemia increases the risk of proarrhythmia with propafenone, which is a class Ic antiarrhythmic. Propafenone itself does not typically lower serum potassium meaningfully.
How serious is the interaction between Dichlorphenamide and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and correct hypokalemia. Consider ECG monitoring if electrolyte disturbance occurs.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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