Drug interactions
Dichlorphenamide + Vancomycin
Severity: Minor
Dichlorphenamide and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide promotes renal potassium loss and metabolic acidosis, and intravenous vancomycin has only rare, weakly documented associations with hypokalemia. The additive effect on potassium is likely small and not well established.
What this interaction means in plain words
Dichlorphenamide and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dichlorphenamide belongs to Miscellaneous; Vancomycin belongs to Anti Bacterial.
Why it happens
Carbonic anhydrase inhibition increases urinary potassium loss; the vancomycin contribution is not well established.
What to do
Check serum potassium and bicarbonate periodically while both drugs are used. Replace potassium if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Vancomycin?
MediHelp rates the interaction as minor. Dichlorphenamide and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dichlorphenamide promotes renal potassium loss and metabolic acidosis, and intravenous vancomycin has only rare, weakly documented associations with hypokalemia. The additive effect on potassium is likely small and not well established.
How serious is the interaction between Dichlorphenamide and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and bicarbonate periodically while both drugs are used. Replace potassium if levels fall.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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