Drug interactions
Dichlorphenamide + Ziprasidone
Severity: Major
Dichlorphenamide and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium loss and can lead to hypokalemia and metabolic acidosis. Low potassium increases the risk of QT prolongation and torsades de pointes with ziprasidone.
What this interaction means in plain words
Dichlorphenamide and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dichlorphenamide belongs to Miscellaneous; Ziprasidone belongs to Central Nervous System.
Why it happens
Carbonic anhydrase inhibition causes kaliuresis, and the resulting hypokalemia potentiates ziprasidone-related QT prolongation.
What to do
Check serum potassium, magnesium and bicarbonate at baseline and periodically, and replace potassium to maintain normal levels. Obtain an ECG if electrolytes are abnormal or symptoms such as palpitations or syncope occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Ziprasidone?
MediHelp rates the interaction as major. Dichlorphenamide and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichlorphenamide causes renal potassium loss and can lead to hypokalemia and metabolic acidosis. Low potassium increases the risk of QT prolongation and torsades de pointes with ziprasidone.
How serious is the interaction between Dichlorphenamide and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium, magnesium and bicarbonate at baseline and periodically, and replace potassium to maintain normal levels. Obtain an ECG if electrolytes are abnormal or symptoms such as palpitations or syncope occur.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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