Drug interactions
Diclofenac + Disulfiram
Severity: Minor
Diclofenac and Disulfiram: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits several CYP enzymes, including CYP2C9, which could modestly increase diclofenac exposure. Higher levels may increase the risk of NSAID-related adverse effects.
What this interaction means in plain words
Diclofenac and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Disulfiram inhibits CYP2C9-mediated diclofenac hydroxylation.
What to do
Use the lowest effective diclofenac dose and monitor for GI, renal and cardiovascular adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Disulfiram?
MediHelp rates the interaction as minor. Diclofenac and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits several CYP enzymes, including CYP2C9, which could modestly increase diclofenac exposure. Higher levels may increase the risk of NSAID-related adverse effects.
How serious is the interaction between Diclofenac and Disulfiram?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for GI, renal and cardiovascular adverse effects.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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