Drug interactions
Diclofenac + Fenoprofen
Severity: Major
Diclofenac and Fenoprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two systemic NSAIDs together adds no proven benefit but increases the risk of GI ulceration, bleeding, renal impairment and cardiovascular events. Duplicate therapy within the same class is generally inappropriate.
What this interaction means in plain words
Diclofenac and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Fenoprofen belongs to Musculoskeletal.
Why it happens
Duplicate cyclooxygenase inhibition causes additive effects on gastric mucosa, platelets and renal prostaglandins.
What to do
Avoid concurrent use and choose a single NSAID at the lowest effective dose. If a switch is needed, stop one before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Fenoprofen?
MediHelp rates the interaction as major. Diclofenac and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two systemic NSAIDs together adds no proven benefit but increases the risk of GI ulceration, bleeding, renal impairment and cardiovascular events. Duplicate therapy within the same class is generally inappropriate.
How serious is the interaction between Diclofenac and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single NSAID at the lowest effective dose. If a switch is needed, stop one before starting the other.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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