Drug interactions
Diclofenac + Feverfew
Severity: Moderate
Diclofenac and Feverfew: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew may inhibit platelet aggregation and could add to the antiplatelet effect of diclofenac, raising the bleeding tendency. Clinical reports are scarce.
What this interaction means in plain words
Diclofenac and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical additive platelet inhibition from feverfew constituents plus NSAID cyclooxygenase inhibition.
What to do
Advise patients to avoid feverfew while on diclofenac and to report bruising or bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Feverfew?
MediHelp rates the interaction as moderate. Diclofenac and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew may inhibit platelet aggregation and could add to the antiplatelet effect of diclofenac, raising the bleeding tendency. Clinical reports are scarce.
How serious is the interaction between Diclofenac and Feverfew?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid feverfew while on diclofenac and to report bruising or bleeding.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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