Drug interactions
Diclofenac + Icosapent
Severity: Minor
Diclofenac and Icosapent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may modestly prolong bleeding time, and diclofenac impairs platelet function and can injure the gastric mucosa. Together the bleeding risk may be slightly increased.
What this interaction means in plain words
Diclofenac and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive mild antiplatelet effects.
What to do
Monitor for signs of bleeding, particularly in patients also taking anticoagulants or with prior gastrointestinal bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Icosapent?
MediHelp rates the interaction as minor. Diclofenac and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent ethyl may modestly prolong bleeding time, and diclofenac impairs platelet function and can injure the gastric mucosa. Together the bleeding risk may be slightly increased.
How serious is the interaction between Diclofenac and Icosapent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly in patients also taking anticoagulants or with prior gastrointestinal bleeding.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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