Drug interactions
Diclofenac + Lumacaftor / ivacaftor
Severity: Moderate
Diclofenac and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor/ivacaftor has mixed effects on CYP2C9, with induction expected from lumacaftor and possible inhibition from ivacaftor. Diclofenac is a CYP2C9 substrate, so its exposure and therefore its efficacy or adverse effects may change unpredictably.
What this interaction means in plain words
Diclofenac and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces and ivacaftor may inhibit CYP2C9, altering diclofenac metabolism.
What to do
Monitor analgesic response and NSAID adverse effects such as GI and renal toxicity, and adjust the diclofenac dose as needed. Use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Diclofenac and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor/ivacaftor has mixed effects on CYP2C9, with induction expected from lumacaftor and possible inhibition from ivacaftor. Diclofenac is a CYP2C9 substrate, so its exposure and therefore its efficacy or adverse effects may change unpredictably.
How serious is the interaction between Diclofenac and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and NSAID adverse effects such as GI and renal toxicity, and adjust the diclofenac dose as needed. Use the lowest effective dose.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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