Drug interactions
Diclofenac + Miconazole vaginal
Severity: Minor
Diclofenac and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole inhibits CYP2C9 and systemic absorption from vaginal use is low but not zero, as the interaction with warfarin has been reported. A meaningful rise in diclofenac exposure is possible but unlikely to be significant.
What this interaction means in plain words
Diclofenac and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Absorbed miconazole may inhibit CYP2C9 metabolism of diclofenac.
What to do
No routine change is needed; monitor for NSAID adverse effects if prolonged or repeated vaginal miconazole is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Miconazole vaginal?
MediHelp rates the interaction as minor. Diclofenac and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole inhibits CYP2C9 and systemic absorption from vaginal use is low but not zero, as the interaction with warfarin has been reported. A meaningful rise in diclofenac exposure is possible but unlikely to be significant.
How serious is the interaction between Diclofenac and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for NSAID adverse effects if prolonged or repeated vaginal miconazole is used.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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