Drug interactions
Diclofenac + Mipomersen
Severity: Moderate
Diclofenac and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mipomersen and diclofenac can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Concurrent use may make liver injury more likely or harder to interpret.
What this interaction means in plain words
Diclofenac and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential through separate mechanisms.
What to do
Monitor ALT, AST and bilirubin regularly and stop the offending agent if significant elevations occur. Consider a non-hepatotoxic analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Mipomersen?
MediHelp rates the interaction as moderate. Diclofenac and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mipomersen and diclofenac can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Concurrent use may make liver injury more likely or harder to interpret.
How serious is the interaction between Diclofenac and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin regularly and stop the offending agent if significant elevations occur. Consider a non-hepatotoxic analgesic.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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