Drug interactions
Diclofenac + Nefazodone
Severity: Moderate
Diclofenac and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants that affect serotonin reuptake can impair platelet function, and with NSAIDs this increases the risk of gastrointestinal bleeding. Nefazodone has weaker serotonin reuptake effect than SSRIs, so the risk is likely smaller but still plausible.
What this interaction means in plain words
Diclofenac and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation plus NSAID mucosal injury.
What to do
Watch for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Nefazodone?
MediHelp rates the interaction as moderate. Diclofenac and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antidepressants that affect serotonin reuptake can impair platelet function, and with NSAIDs this increases the risk of gastrointestinal bleeding. Nefazodone has weaker serotonin reuptake effect than SSRIs, so the risk is likely smaller but still plausible.
How serious is the interaction between Diclofenac and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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