Drug interactions
Diclofenac + Penbutolol
Severity: Moderate
Diclofenac and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can attenuate the blood pressure lowering effect of beta-blockers, particularly with sustained use. Blood pressure control may worsen and renal function can be affected.
What this interaction means in plain words
Diclofenac and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and water retention opposes the antihypertensive effect.
What to do
Monitor blood pressure when starting or stopping diclofenac, and adjust antihypertensive therapy if needed. Use the shortest possible NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Penbutolol?
MediHelp rates the interaction as moderate. Diclofenac and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can attenuate the blood pressure lowering effect of beta-blockers, particularly with sustained use. Blood pressure control may worsen and renal function can be affected.
How serious is the interaction between Diclofenac and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping diclofenac, and adjust antihypertensive therapy if needed. Use the shortest possible NSAID course.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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