Drug interactions
Diclofenac + Phenindione
Severity: Major
Diclofenac and Phenindione: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is an oral anticoagulant and diclofenac impairs platelet function and can cause GI bleeding. Combined use increases hemorrhage risk, and NSAIDs may also displace anticoagulants from protein binding.
What this interaction means in plain words
Diclofenac and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on hemostasis from anticoagulation and NSAID antiplatelet and mucosal effects.
What to do
Avoid the combination where possible and use paracetamol instead. If necessary, monitor INR and bleeding signs closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Phenindione?
MediHelp rates the interaction as major. Diclofenac and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is an oral anticoagulant and diclofenac impairs platelet function and can cause GI bleeding. Combined use increases hemorrhage risk, and NSAIDs may also displace anticoagulants from protein binding.
How serious is the interaction between Diclofenac and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol instead. If necessary, monitor INR and bleeding signs closely and consider gastroprotection.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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