Drug interactions
Diclofenac + Quinapril
Severity: Moderate
Diclofenac and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can reduce the blood pressure lowering effect of quinapril. The combination can also cause acute kidney injury and hyperkalaemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Diclofenac and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Monitor blood pressure, creatinine and potassium after starting, and ensure adequate hydration. Use the lowest effective diclofenac dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Quinapril?
MediHelp rates the interaction as moderate. Diclofenac and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can reduce the blood pressure lowering effect of quinapril. The combination can also cause acute kidney injury and hyperkalaemia, particularly in older or volume-depleted patients.
How serious is the interaction between Diclofenac and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting, and ensure adequate hydration. Use the lowest effective diclofenac dose for the shortest time.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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