Drug interactions
Diclofenac + Rifampin
Severity: Minor
Diclofenac and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong inducer of drug-metabolizing enzymes and can reduce diclofenac plasma concentrations. This may lead to a weaker analgesic or anti-inflammatory response.
What this interaction means in plain words
Diclofenac and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induces CYP2C9 and other enzymes, increasing the metabolic clearance of diclofenac.
What to do
Monitor for reduced pain relief and adjust diclofenac within the approved maximum dose or choose an alternative analgesic if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Rifampin?
MediHelp rates the interaction as minor. Diclofenac and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin is a strong inducer of drug-metabolizing enzymes and can reduce diclofenac plasma concentrations. This may lead to a weaker analgesic or anti-inflammatory response.
How serious is the interaction between Diclofenac and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pain relief and adjust diclofenac within the approved maximum dose or choose an alternative analgesic if needed.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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