Drug interactions
Diclofenac + Telmisartan-amlodipine
Severity: Moderate
Diclofenac and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can blunt the blood pressure lowering effect of telmisartan and, together with an angiotensin receptor blocker, may impair renal function, particularly in elderly or volume-depleted patients. Potassium can also rise.
What this interaction means in plain words
Diclofenac and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and sodium excretion, which opposes ARB effect and reduces glomerular filtration.
What to do
Use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, creatinine and potassium. Consider paracetamol or a topical agent instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Diclofenac and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can blunt the blood pressure lowering effect of telmisartan and, together with an angiotensin receptor blocker, may impair renal function, particularly in elderly or volume-depleted patients. Potassium can also rise.
How serious is the interaction between Diclofenac and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, creatinine and potassium. Consider paracetamol or a topical agent instead.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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