Drug interactions
Diclofenac + Temocillin
Severity: Minor
Diclofenac and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac may modestly reduce renal clearance of penicillins, and both drugs are highly protein bound. Clinically important changes in temocillin levels are not well documented, and the effect is generally small.
What this interaction means in plain words
Diclofenac and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion and protein binding.
What to do
No routine adjustment is needed; monitor renal function in patients with impaired kidney function receiving both.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Temocillin?
MediHelp rates the interaction as minor. Diclofenac and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diclofenac may modestly reduce renal clearance of penicillins, and both drugs are highly protein bound. Clinically important changes in temocillin levels are not well documented, and the effect is generally small.
How serious is the interaction between Diclofenac and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function in patients with impaired kidney function receiving both.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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