Drug interactions
Diclofenac + Ticarcillin
Severity: Moderate
Diclofenac and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function and is renally cleared, and diclofenac also affects platelets and renal function. Combined use may add to bleeding tendency and slow penicillin clearance in patients with reduced renal function.
What this interaction means in plain words
Diclofenac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet inhibition and competition for renal tubular secretion.
What to do
Monitor for bleeding and renal function, especially with high ticarcillin doses or renal impairment. Adjust the ticarcillin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Ticarcillin?
MediHelp rates the interaction as moderate. Diclofenac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin can impair platelet function and is renally cleared, and diclofenac also affects platelets and renal function. Combined use may add to bleeding tendency and slow penicillin clearance in patients with reduced renal function.
How serious is the interaction between Diclofenac and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function, especially with high ticarcillin doses or renal impairment. Adjust the ticarcillin dose to renal function.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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