Drug interactions
Diclofenac + Valoctocogene roxaparvovec
Severity: Moderate
Diclofenac and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes raised liver enzymes, and diclofenac can cause hepatotoxicity. Combining them may complicate the interpretation of liver enzyme rises and increase liver injury risk.
What this interaction means in plain words
Diclofenac and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxic potential; gene therapy-related hepatic transaminitis plus NSAID-induced liver injury.
What to do
Monitor liver enzymes closely as per gene therapy schedule and use a non-hepatotoxic analgesic such as low-dose paracetamol where appropriate. Review hepatotoxic medicines before and after infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Diclofenac with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Diclofenac and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes raised liver enzymes, and diclofenac can cause hepatotoxicity. Combining them may complicate the interpretation of liver enzyme rises and increase liver injury risk.
How serious is the interaction between Diclofenac and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely as per gene therapy schedule and use a non-hepatotoxic analgesic such as low-dose paracetamol where appropriate. Review hepatotoxic medicines before and after infusion.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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