Drug interactions
Diclofenac + Vorapaxar
Severity: Major
Diclofenac and Vorapaxar: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar blocks PAR-1 platelet activation and diclofenac inhibits platelet function and irritates the GI tract. Together they increase the risk of bleeding.
What this interaction means in plain words
Diclofenac and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effect from PAR-1 antagonism and NSAID cyclooxygenase inhibition, with NSAID mucosal injury.
What to do
Avoid regular NSAID use with vorapaxar where possible, and use paracetamol instead. If needed, monitor for bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Vorapaxar?
MediHelp rates the interaction as major. Diclofenac and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar blocks PAR-1 platelet activation and diclofenac inhibits platelet function and irritates the GI tract. Together they increase the risk of bleeding.
How serious is the interaction between Diclofenac and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with vorapaxar where possible, and use paracetamol instead. If needed, monitor for bleeding and consider gastroprotection.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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