Drug interactions
Dicyclomine + Henbane
Severity: Major
Dicyclomine and Henbane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are potent antimuscarinic alkaloids. Combined with dicyclomine this can cause marked anticholinergic toxicity, including confusion, hyperthermia, tachycardia, urinary retention and ileus.
What this interaction means in plain words
Dicyclomine and Henbane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive muscarinic receptor antagonism from the belladonna alkaloids in henbane.
What to do
Avoid the combination; henbane has a variable alkaloid content and a narrow safety margin. If exposure occurs, monitor for anticholinergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
- Amantadine + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Henbane?
MediHelp rates the interaction as major. Dicyclomine and Henbane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Henbane contains hyoscyamine and scopolamine, which are potent antimuscarinic alkaloids. Combined with dicyclomine this can cause marked anticholinergic toxicity, including confusion, hyperthermia, tachycardia, urinary retention and ileus.
How serious is the interaction between Dicyclomine and Henbane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; henbane has a variable alkaloid content and a narrow safety margin. If exposure occurs, monitor for anticholinergic toxicity.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Imipramine, Pramlintide. The full list is on the Dicyclomine page.
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