Drug interactions
Clozapine + Dicyclomine
Severity: Major
Clozapine and Dicyclomine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly anticholinergic and already causes severe constipation and gastrointestinal hypomotility. Adding dicyclomine raises the risk of serious constipation, ileus, urinary retention, tachycardia and delirium.
What this interaction means in plain words
Clozapine and Dicyclomine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade leading to reduced gastrointestinal motility and other anticholinergic effects.
What to do
Avoid the combination where possible; if used, monitor bowel function closely, treat constipation early, and reassess the need for dicyclomine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dicyclomine
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
- Amantadine + Dicyclomine Moderate
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dicyclomine?
MediHelp rates the interaction as major. Clozapine and Dicyclomine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly anticholinergic and already causes severe constipation and gastrointestinal hypomotility. Adding dicyclomine raises the risk of serious constipation, ileus, urinary retention, tachycardia and delirium.
How serious is the interaction between Clozapine and Dicyclomine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor bowel function closely, treat constipation early, and reassess the need for dicyclomine.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Henbane, Imipramine, Pramlintide. The full list is on the Dicyclomine page.
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