Drug interactions
Dicyclomine + Imipramine
Severity: Major
Dicyclomine and Imipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has marked anticholinergic activity, so combined use adds to the anticholinergic burden. This can produce severe constipation, ileus, urinary retention, tachycardia, blurred vision, delirium and heat intolerance.
What this interaction means in plain words
Dicyclomine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dicyclomine belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid the combination if possible, particularly in older adults. If used, monitor for ileus, urinary retention, confusion and tachycardia and reduce doses as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
- Amantadine + Dicyclomine Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dicyclomine with Imipramine?
MediHelp rates the interaction as major. Dicyclomine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipramine has marked anticholinergic activity, so combined use adds to the anticholinergic burden. This can produce severe constipation, ileus, urinary retention, tachycardia, blurred vision, delirium and heat intolerance.
How serious is the interaction between Dicyclomine and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, particularly in older adults. If used, monitor for ileus, urinary retention, confusion and tachycardia and reduce doses as needed.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Pramlintide. The full list is on the Dicyclomine page.
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