Drug interactions
Didanosine + Nelfinavir
Severity: Minor
Didanosine and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir should be taken with food, whereas didanosine is taken on an empty stomach, so a timing interaction exists. The buffered formulation may also change nelfinavir absorption, with the clinical effect uncertain.
What this interaction means in plain words
Didanosine and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Nelfinavir belongs to Anti Virals.
Why it happens
Conflicting food requirements and possible pH-related absorption changes.
What to do
Give nelfinavir with food at least 2 hours before or 1 hour after didanosine. Monitor virologic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Didanosine with Nelfinavir?
MediHelp rates the interaction as minor. Didanosine and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir should be taken with food, whereas didanosine is taken on an empty stomach, so a timing interaction exists. The buffered formulation may also change nelfinavir absorption, with the clinical effect uncertain.
How serious is the interaction between Didanosine and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give nelfinavir with food at least 2 hours before or 1 hour after didanosine. Monitor virologic response.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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