Drug interactions
Didanosine + Ublituximab
Severity: Moderate
Didanosine and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and raises infection risk in an already immunocompromised patient with HIV. It does not change didanosine pharmacokinetics, so the problem is additive immunosuppression and not reduced didanosine efficacy.
What this interaction means in plain words
Didanosine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression; no direct effect on didanosine exposure.
What to do
Screen for hepatitis B before ublituximab and monitor CD4 count, viral load and for infections during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Didanosine with Ublituximab?
MediHelp rates the interaction as moderate. Didanosine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and raises infection risk in an already immunocompromised patient with HIV. It does not change didanosine pharmacokinetics, so the problem is additive immunosuppression and not reduced didanosine efficacy.
How serious is the interaction between Didanosine and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for hepatitis B before ublituximab and monitor CD4 count, viral load and for infections during therapy.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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