Drug interactions
Dienogest / estradiol valerate + Imatinib
Severity: Minor
Dienogest / estradiol valerate and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dienogest and estradiol are metabolised in part by CYP3A4, so imatinib may raise their exposure. This may increase estrogenic or progestogenic effects such as nausea, breast tenderness, headache and bleeding irregularities.
What this interaction means in plain words
Dienogest / estradiol valerate and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by imatinib reduces hormone clearance.
What to do
Monitor for hormonal adverse effects and adjust therapy if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Imatinib?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dienogest and estradiol are metabolised in part by CYP3A4, so imatinib may raise their exposure. This may increase estrogenic or progestogenic effects such as nausea, breast tenderness, headache and bleeding irregularities.
How serious is the interaction between Dienogest / estradiol valerate and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hormonal adverse effects and adjust therapy if they become troublesome.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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