Drug interactions
Dienogest / estradiol valerate + Lapatinib
Severity: Minor
Dienogest / estradiol valerate and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may modestly increase exposure to estradiol and dienogest, both partly metabolized by CYP3A4. This may cause estrogenic or progestogenic adverse effects such as breast tenderness, headache and irregular bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lapatinib inhibits CYP3A4, reducing hormone metabolism.
What to do
No empiric adjustment is needed. Monitor for hormonal adverse effects, and review use of hormonal therapy in hormone-sensitive cancer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Lapatinib?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib may modestly increase exposure to estradiol and dienogest, both partly metabolized by CYP3A4. This may cause estrogenic or progestogenic adverse effects such as breast tenderness, headache and irregular bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed. Monitor for hormonal adverse effects, and review use of hormonal therapy in hormone-sensitive cancer.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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