Drug interactions
Dienogest / estradiol valerate + Mifepristone
Severity: Moderate
Dienogest / estradiol valerate and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone antagonizes progesterone receptors and can reduce the contraceptive and cycle-control effect of the progestin. It may also increase hormone exposure through CYP3A4 inhibition, with possible breakthrough bleeding or breast tenderness.
What this interaction means in plain words
Dienogest / estradiol valerate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Progesterone receptor antagonism combined with CYP3A4 inhibition.
What to do
Use an additional non-hormonal contraceptive method during and after mifepristone treatment. Monitor for bleeding irregularities and estrogenic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dienogest / estradiol valerate and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Mifepristone?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone antagonizes progesterone receptors and can reduce the contraceptive and cycle-control effect of the progestin. It may also increase hormone exposure through CYP3A4 inhibition, with possible breakthrough bleeding or breast tenderness.
How serious is the interaction between Dienogest / estradiol valerate and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional non-hormonal contraceptive method during and after mifepristone treatment. Monitor for bleeding irregularities and estrogenic adverse effects.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
