Drug interactions
Dienogest / estradiol valerate + Nicardipine
Severity: Minor
Dienogest / estradiol valerate and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit CYP3A4 and slightly raise exposure to estradiol and dienogest. This may increase estrogenic or progestogenic adverse effects such as breast tenderness, nausea, headache and irregular bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nicardipine inhibits CYP3A4, which contributes to the metabolism of dienogest and estradiol.
What to do
No dose change is generally needed; review hormonal adverse effects and bleeding pattern at follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Dienogest / estradiol valerate with Nicardipine?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may inhibit CYP3A4 and slightly raise exposure to estradiol and dienogest. This may increase estrogenic or progestogenic adverse effects such as breast tenderness, nausea, headache and irregular bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; review hormonal adverse effects and bleeding pattern at follow-up.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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