Drug interactions
Dienogest / estradiol valerate + Prednisone
Severity: Minor
Dienogest / estradiol valerate and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptive estrogens reduce clearance of prednisolone, raising corticosteroid exposure and effect. Prednisone is not a clinically meaningful inducer, so loss of contraceptive efficacy is not expected.
What this interaction means in plain words
Dienogest / estradiol valerate and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens inhibit metabolism and reduce binding changes of prednisolone, increasing its exposure; prednisone itself has no relevant CYP3A4 induction.
What to do
No back-up contraception is required because of prednisone. Monitor for enhanced corticosteroid effects and reduce the prednisone dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Prednisone?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptive estrogens reduce clearance of prednisolone, raising corticosteroid exposure and effect. Prednisone is not a clinically meaningful inducer, so loss of contraceptive efficacy is not expected.
How serious is the interaction between Dienogest / estradiol valerate and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No back-up contraception is required because of prednisone. Monitor for enhanced corticosteroid effects and reduce the prednisone dose if they appear.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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