Drug interactions
Dienogest / estradiol valerate + Quinidine
Severity: Minor
Dienogest / estradiol valerate and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may weakly inhibit CYP3A4 and slightly increase exposure to dienogest and estradiol. The clinical effect is expected to be small and mainly hormonal adverse effects such as breast tenderness or irregular bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinidine may weakly inhibit CYP3A4-mediated hormone metabolism.
What to do
No dose change is needed; monitor for breast tenderness, headache, nausea or irregular bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Quinidine?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine may weakly inhibit CYP3A4 and slightly increase exposure to dienogest and estradiol. The clinical effect is expected to be small and mainly hormonal adverse effects such as breast tenderness or irregular bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for breast tenderness, headache, nausea or irregular bleeding.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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