Drug interactions
Dienogest / estradiol valerate + Tranexamic acid
Severity: Contraindicated
Dienogest / estradiol valerate and Tranexamic acid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral tranexamic acid is antifibrinolytic and estrogen-containing contraceptives are prothrombotic. Together they raise the risk of venous and arterial thrombosis, and oral tranexamic acid labeling contraindicates use with combined hormonal contraceptives.
What this interaction means in plain words
Dienogest / estradiol valerate and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive prothrombotic effects of fibrinolysis inhibition and estrogen-induced increases in clotting factors.
What to do
Avoid the combination; use non-hormonal or progestin-only contraception while taking tranexamic acid, or choose another heavy-bleeding treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranexamic acid
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
- Alteplase + Tranexamic acid Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Tranexamic acid?
MediHelp rates the interaction as contraindicated. Dienogest / estradiol valerate and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral tranexamic acid is antifibrinolytic and estrogen-containing contraceptives are prothrombotic. Together they raise the risk of venous and arterial thrombosis, and oral tranexamic acid labeling contraindicates use with combined hormonal contraceptives.
How serious is the interaction between Dienogest / estradiol valerate and Tranexamic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use non-hormonal or progestin-only contraception while taking tranexamic acid, or choose another heavy-bleeding treatment.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel, Ethinyl estradiol-norgestimate. The full list is on the Tranexamic acid page.
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