Drug interactions
Dienogest / estradiol valerate + Verapamil
Severity: Minor
Dienogest / estradiol valerate and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase exposure to dienogest and estradiol, possibly causing hormonal adverse effects such as nausea, breast tenderness, headache or irregular bleeding. The effect is expected to be modest.
What this interaction means in plain words
Dienogest / estradiol valerate and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Verapamil inhibits CYP3A4, the main metabolic pathway for dienogest and a contributor for estradiol.
What to do
No routine change is needed; ask about hormonal adverse effects and reassess the regimen if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Verapamil?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may increase exposure to dienogest and estradiol, possibly causing hormonal adverse effects such as nausea, breast tenderness, headache or irregular bleeding. The effect is expected to be modest.
How serious is the interaction between Dienogest / estradiol valerate and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; ask about hormonal adverse effects and reassess the regimen if they occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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