Drug interactions
Diethylpropion + Linezolid
Severity: Contraindicated
Diethylpropion and Linezolid: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic, and with an MAO inhibitor like linezolid it may produce a hypertensive crisis.
What this interaction means in plain words
Diethylpropion and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition potentiates sympathomimetic catecholamine release.
What to do
Avoid concurrent use. Stop diethylpropion and use an alternative antibiotic; monitor blood pressure if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
- Linezolid 600 mg Film-Coated Tablets - SmPC sections 4.3/4.5 (class statement: directly and indirectly acting sympathomimetic agents; "directly and indirectly acting sympathomimetic agents (including the adrenergic bronchodilators, pseudoephedrine and phenylpropanolamine)") — electronic medicines compendium (UK SmPC)
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Diethylpropion with Linezolid?
MediHelp rates the interaction as contraindicated. Diethylpropion and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diethylpropion is a sympathomimetic anorectic, and with an MAO inhibitor like linezolid it may produce a hypertensive crisis.
How serious is the interaction between Diethylpropion and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Stop diethylpropion and use an alternative antibiotic; monitor blood pressure if exposure occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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