Drug interactions
Diethylpropion + Maprotiline
Severity: Major
Diethylpropion and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant, and maprotiline can change its pressor effects, potentially causing hypertension or arrhythmia. Both drugs also lower the seizure threshold.
What this interaction means in plain words
Diethylpropion and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Maprotiline blocks norepinephrine reuptake and neuronal uptake of indirect sympathomimetics, altering pressor response; additive seizure-threshold lowering.
What to do
Avoid the combination where possible. If used, monitor blood pressure, heart rate and seizure activity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Diethylpropion with Maprotiline?
MediHelp rates the interaction as major. Diethylpropion and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diethylpropion is a sympathomimetic stimulant, and maprotiline can change its pressor effects, potentially causing hypertension or arrhythmia. Both drugs also lower the seizure threshold.
How serious is the interaction between Diethylpropion and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor blood pressure, heart rate and seizure activity.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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